Sensitivity Pattern of Micro Organisms of Septicemia in Neonatal Intensive Care Unit of a Tertiary Hospital, Bangladesh

Neonatal septicemia is a clinical syndrome of systemic illness accompanied by bacteremia occurring in the first 28 days of life. Microorganism causing neonatal septicemia varies from country to country and region to region and time to time. In many situations, conventional antibiotics are not sensitive to causative micro-organism. Our aim of the study is to identify causative organism and sensitivity pattern of micro-organism in Neonatal Intensive Care Unit, (NICU) Methods & Subject: Total 300 patients were enrolled in this study with clinically diagnosed septicemia with prior antibiotic treatment or not. This study was done in NICU of tertiary Hospital, Chittagong Medical College, Bangladesh during the period of January 2013 to July 2014. Blood culture was done in Bact/Alerd 3D system. Result: Out of 300 cases, 204 cases were culture negative and 96 cases (32%) were culture positive. Klebsiella is the commonest causative organism 52(54.17%), followed by Pseudomonas 16(16.67%), Acinetobacter 14(14.58%), S. aureus 6(6.25%), E.coli 6(6.25%), E. coli with other Coliform 2(2.08%). In this study, sensitivity of Klebsiella was mostly to Ciprofloxacin, Imipenem, Azithromycin, Co-trimoxazole, Piperaciline and Tazobactam. Sensitivity to Pseudomonas was mostly to Amikacin, Imipenem, Ciprofloxacin, Azithromycin and Cefoperazone with Sulbactum.. Sensitivity to Acinetobactor was mostly to Amikacin, Imipenem, Ciprofloxacin, Netilmicin. Sensitivity to S. aureus was mostly to Vancomycine, Amikacin, Imipenem, Meropenem.. Sensitivity of E.coli was mostly to Amikacin, Ciprofloxacin, Ceftazidin. Most of the culture positive organisms not sensitive to conventional Ampicilin, Gentamycin. Conclusion: Microorganisms identified causing neonatal septicemia in our region are Klebsiella, Pseudomonas, Acinetobactor, E. coli and Enterobector. Antibiotic sensitive to identified microorganism were Amikacin, Ciprofloxacin, Levofloxacin, Imipenem, Meropenem, Vancomycin and Ceftazidim..Conventional Ampicillin sensitivity is not detected and Gentamicin sensitivity is also low.